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All Publications

221. Chen, Y.; Xue, T.; Chen, C.; Jang, S.; Braun, P.V.; Cheng, J.; Evans, C.M. "Helical peptide structure improves conductivity and stability of solid electrolytes", Nature Materials, 2024, 1-8. [PDF] [Link] [SI]

220. Liu, X.; Huang, J.; Wang, J.; Sheng, H.; Yuan, Z.; Wang, W.; Li, W.; Song, Z.; Cheng, J. "Accelerated and controlled polymerization of N-carboxyanhydrides assisted by acids", CCS Chemistry, 2024, 0:1–28. [
PDF] [Link] [SI]

219. Ekatan, S.R.; Xue, T; Song, Z.; Yang, T.; Ndaya, D.; Shaw, M.T.; Cheng, J.; Lin, Y. "Thermomechanical Properties of Solid 'Liquid Crystalline' Films from Hot-Pressed Synthetic Polypeptides of Various Macromolecular Architectures", Macromolecules, 2024, 57 (5), 2008-2018. [
PDF] [Link] [SI]

218. Yang, T.; Xue, T.; Mao, J.; Chen, Y.; Tian, H.; Bartolome, A.; Xia, H.; Yao, X.; Kumar, C.V.; Cheng, J.; Lin,Y. "Tailoring synthetic polypeptide design for directed fibril superstructure formation and enhanced hydrogel properties", J. Am. Chem. Soc, 2024, 146 (9), 5823-5833. [PDF] [Link] [SI]

217. Chen, Y.; Jiang, Y.; Xue, T.; Cheng, J. "Strategies for the eradication of intracellular bacterial pathogens", Biomater.  Sci., 2024, 12, 1115-1130.​ [
PDF] [Link]

216. Ji, G.; Zheng, X.; Hou, X.; Sun, X.; Wang, S.; Li, X.; Cheng, J.; Song, Z. "Modulation of polymerization rate of N-carboxyanhydrides in a biphasic system", CCL, 2024, 35 (1), 108872. [
PDF] [Link] [SI]

215. Bo, Y.; Zhou, J.; Cai, K.; Wang, Y.; Feng, Y.; Li, W.; Jiang, Y.; Kuo, S.H.; Roy, J.; Anorma, C.; Gardner, S.H.; Luu, L.M.; Lau, G.W.; Bao, Y.; Chan, J.; Wang, H.; Cheng, J. "Leveraging intracellular ALDH1A1 activity for selective cancer stem-like cell labeling and targeted treatment via in vivo click reaction", Proceedings of the National Academy of Sciences 2023, 120(36), e2302342120. [PDF[Link]

214. Wang, W.; Fu, H.; Lin, Y.; Cheng, J.; Song, Z. "Cooperative Covalent Polymerization of N-carboxyanhydrides: from Kinetic Studies to Efficient Synthesis of Polypeptide Materials", Accounts of Materials Research 2023, 4, 604-615. [
PDF[Link]

213. Yin, Q.; Luo, W.; Mallajosyula, V.; Bo, Y.; Guo, J.; Xie, J.; Sun, M.; Verma, R.; Li, C.; Constantz, C.; Wagar, L.; Li, J.; Sola, E.; Gupta, N.; Wang, C.; Kask, O.; Chen, X.; Yuan, X.; Wu, N.C.; Rao, J.; Chien, Y-H.; Cheng, J.; Pulendran, B.; Davis, M.M. "A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2", Nature Materials 2023, 22, 380-390. [PDF[Link] [SI]

212. Amaral, I.; Fernandes, H.; Li, J.; Ma, M.; Sriram, G.; Wang, Z.; Yu, B.; Cheng, J.; Southall, M. "Outstanding Reviewers for Biomaterials Science in 2021", Biomaterials Science 2022, 10, 3670-3670. [PDF[Link]

211. Fu, H.; Baumgartner, R.; Song, Z.; Chen, C.; Cheng, J.; Lin, Y. "Generalized model of cooperative covalent polymerization: connecting the supramolecular binding interactions with the catalytic behavior", Macromolecules 2022, 6, 2041-2050.
 [PDF] [Link]

210. Cheng, J.; Southall, M.E. "Ten years of Biomaterials Science", Biomaterials Science 2022, 10, 6339-6340. [PDF[Link]


209. Wang, X.; Zhao, Z.; Xue, T.; Tan, Z.; Song, Z.; Wei, S.; Bo, Y.; Wang, Y.; Cheng, J. "Nanoengineered polypeptides from tetraphenylethylene-functionalized N-carboxyanhydride: Synthesis, self-assembly and intrinsic aggregation-induced emission", Progress in Natural Science: Materials International 2021, 31, 541-545. [PDF[Link] [SI]

208. Yang, Y.; Ying, H.; Li, Z.; Wang, J.; Ferguson, A.; Zhang, Y.; Cheng, J. “Near quantitative synthesis of urea macrocycles enabled by bulky N-substituent”, Nature Communications 2021, 12, 1572. [PDF] [Link] [SI]

207. Jiang, Y.; Chen, Y.; Song, Z.; Tan, Z.; Cheng, J. “Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation” Advanced Drug Delivery Reviews 2021, 170, 261-280. [PDF] [Link]

206. Xia, Y.; Song, Z.; Tan, Z.; Xue, T. Wei, S.; Zhu, L.; Yang, Y.; Fu, H.; Jiang, Y.; Lin, Y.; Lu, Y.; Ferguson, A.L.; Cheng, J. “Accelerated polymerizaton of N-carboxyanhydrides catalyzed by crown ether” Nature Communications 2021, 12, 372. [PDF] [Link] [SI]

205. Jiang, Y.; Han, M.; Bo, Y.; Feng, Y.; Li, W.; Wu, J.R.; Song, Z.; Zhao, Z.; Tan, Z.; Chen, Y.; Xue, T.; Fu, Z.; Kuo, S.H.; Lau, G.W.; Lujiten, E.; Cheng, J. ““Metaphilic” Cell-Penetrating Polypeptide-Vancomycin Conjugate Efficiently Eradicates Intracellular Bacteria via a Dual Mechanism” ACS central science. 2020, 6, 2267–2276. [PDF[Link] [SI]

204. Song, Z.; Khaw, Y. M.; Pacheco, L. A.; Tseng, K.-Y.; Tan, Z.; Cai, K.; Ponnusamy, E.; Cheng, J.*, Inoue, M.* “Induction of a higher-ordered architecture in glatiramer acetate improves its biological efficiency in a multiple sclerosis animal model”, Biomater. Sci. 2020, 8, 5271. [PDF[Link] [SI]
 

203. Song, Z.; Chen, X.; Wang, Z.; King, S.; Yan, H.; Cai, K.; Cheng, J. “Potential bleach activators with improved imide hydrolytic stability”, International Journal of Industrial Chemistry, 2020, 11, 177-185. [PDF] [Link]

202. Wang, S.; Yang, Y.; Ying, H.; Jing, X.; Wang, B.; Zhang, Y.; Cheng, J. “Recyclable, Self-Healable, and Highly Malleable Poly(urethane-urea)s with Improved Thermal and Mechanical Performances”, ACS Appl. Mater. Interfaces, 2020, 12, 35403-35414. [PDF] [Link] [SI]

201. Xue, T.; Song, Z.; Wang, Y.; Zhu, B.; Zhao, Z.; Tan, Z.; Wang, X.; Xia, Y.; Cheng, J. “Streamlined synthesis of PEG-polypeptides directly from amino acids”, Macromolecules, 2020, 53, 6589-6597. [PDF] [Link] [SI]

200. Shen, L.; Cai, K.; Yu, J.; Cheng, J. “Facile Click-Mediated Cell Imaging Strategy of Liposomal Azido Mannosamine Lipids via Metabolic or Nonmetabolic Glycoengineering”, ACS Omega, 2020, 5, 14111-14115. [PDF[Link] [SI]

199. Lv, S.; Kim, H.; Feng, L.; Song, Z.; Yang, Y.; Baumgartner, R.; Tseng, K.-Y.; Dillon, S.; Leal, C.; Yin, L.; Cheng, J. “Unimolecular Polypeptide Micelles via Ultra-fast Polymerization of N-Carboxyanhydrides”, J. Am. Chem. Soc. 2020, 142, 8570-8574. [PDF] [Link] [SI]

198. Bo, Y.; Jiang, Y.; Chen, K.; Cai, K.; Li, W.; Roy, J.; Bao, Y.; Cheng, J. “Targeting Infected Host Cells in vivo via Responsive Azido-Sugar Mediated Metabolic Cell Labeling Followed by Click Reaction”, Biomaterials, 2020, 238, 119843. [PDF] [Link] [SI]

197. Song, Z.; Tan, Z.; Zheng, X.; Fu, Z.; Ponnusamy, E.; Cheng, J. “Manipulating the helix-coil transition profile of synthetic polypeptides through leveraging side-chain molecular interactions”, Polym. Chem., 2020, 11, 1445-1449. [PDF] [Link] [SI]

196. Song, Z.; Fu, H.; Baumgartner, R.; Zhu, L.; Shih, K.-C.; Xia, Y.; Zheng, X.; Yin, L.; Chipot, C.; Lin, Y.; Cheng, J. “Enzyme-mimetic self-catalyzed polymerization of polypeptide helices” Nature Communications, 2019, 10, 5470. [PDF] [Link

195. Song, Z.; Fu, H.; Wang, J.; Hui, J.; Xue, T.; Pacheco, L.A.; Yan, H.; Baumgartner, R.; Wang, Z.; Xia, Y.; Wang, X.; Yin, L.; Chen. C.; Roderiguez-Lopez. J.; Ferguson. A.; Lin. Y.; Cheng. J.“Synthesis of polypeptides via bioinspired polymerization of in situ purified N-carboxyanhydrides”, PNAS, 2019, 116, 10658-10663. [PDF] [Link] [SI]

194. Chen, C.; Fu, H.; Baumgartner, R.; Song, Z.; Lin, Y.; Cheng, J. “Proximity-Induced Cooperative Polymerization in “Hinged” Helical Polypeptides”, J. Am. Chem. Soc., 2019, 141, 8680-8693. [PDF] [Link]

193. Wang, X.; Song, Z.; Tan, Z.; Zhu, L.; Xue, T.; Lv, S.; Fu, Z.; Zheng, X.; Ren, J.; Cheng, J. “Facile Synthesis of Helical Multiblock Copolypeptides: Minimal Side Reactions with Accelerated Polymerization of N‑Carboxyanhydrides” ACS Macro Lett.; 2019, 8, 1517−1521. [PDF] [Link] [SI]

192. Chen, X.; Zheng, G.; Cheng, J.; Yang, Y. “Supramolecular Nanotheranostics”, Theranostics, 2019, 9, 3014-3016. [PDF] [Link]

191. Ying, H.; Yang, Y.; Cai, K.; Cheng, J. “Hindered Urea Bond: A Bilaterally Responsive Chemistry to Hydrogen Peroxide”, European Journal of Organic Chemistry, 2019, 4, 728-731. [PDF] [Link]

190. Wang, H.; Liu, Y.; Xu, M.; Cheng, J. “Azido-Galactose Outperforms Azido-Mannose for Metabolic Labeling and Targeting of Hepatocellular Carcinoma” Biomater. Sci., 2019, 7, 4166-4173. [PDF] [Link] [SI]

189. Shen, L.; Cai, K.; Yu, J.; Cheng, J. “Novel Liposomal Azido Mannosamine Lipids on Metabolic Cell Labelling and Imaging via Cu-free Click Chemistry” Bioconjugate Chem, 2019, 30, 9, 2317-2322. [PDF] [Link] [SI]

188. Wang, H.; Bo, Y.; Liu, Y.; Xu. M.; Cai. K.; Wang. R.; Cheng, J.; “In Vivo Cancer Targeting via Glycopolyester Nanoparticle Mediated Metabolic Cell Labeling Followed by Click Reaction” Biomaterials, 2019, 119305. [PDF] [Link]

187. Song, Z.; Tan, Z.; Cheng, J.; “Recent Advances and Future Perspectives of Synthetic Polypeptides from N‑Carboxyanhydrides” Macromolecules, 2019, 52, 8521-8539. [PDF] [Link]

186. Jia, Y.; Ying, H.; Zhang, Y.; He, H.; Cheng, J. “Reconfigurable Poly (urea-urethane) Thermoset Based on Hindered Urea Bonds with Triple-shape Memory Performance”, Macromol. Chem. Phys., 2019, 1900148. [PDF] [Link] [SI]

185. Mei, Y.; Wang, R.; Jiang, W.; Bo, Y.; Zhang, T.; Yu, J.; Cheng, M.; Wu, Y.; Cheng, J.; Ma, W.;“Recent progress in nanomaterials for nucleic acid delivery in cancer immunotherapy” Biomater. Sci., 2019, 7, 2640-2651.[PDF] [Link]

184. Wang, H.; Song, Z.; Lao, Y.; Xu, X.; Gong, J.; Cheng, D.; Chakraborty, S.; Park, J.S.; Li, M.; Huang, D.; Yin, L.; Cheng, J.; Leong, K.W. “Nonviral Gene Editing via CRISPR/Cas9 Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide”, PNAS, 2018, 115, 4903-4908. [PDF] [Link] [SI]

183. Song, Z.; Fu, H.; Wang, R.; Pacheco, L.A.; Wang, X.; Lin, Y.; Cheng, J. “Secondary structures in synthetic polypeptides from N-carboxyanhydrides: design, modulation, association, and material applications”, Chem. Soc. Rev., 2018, 47, 7401-7425. [PDF] [Link]

182. Lv, S.; Wu, Y.; Cai, K.; He, H.; Li, Y.; Lan, M.; Chen, x.; Cheng, J.; Yin, L. “High Drug Loading and Sub-Quantitative Loading Efficiency of Polymeric Micelles Driven by Donor-Receptor Coordination Interactions”, J. Am. Chem. Soc., 2018, 140, 1235–1238. [PDF] [Link] [SI]

181. Zhang, Y.; Cai, K.; Li, C.; Guo, Q.; Chen, Q.; He, X.; Liu, L.; Zhang, Y.; Lu, Y.; Chen, X.; Sun, T.; Huang, Y.; Cheng, J.; Jiang, C. “Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy”, Nano Lett., 2018, 18, 1908–1915. [PDF] [Link] [SI]

180. He, H.; Chen, Y.; Li, Y.; Song, Z.; Zhong, Y.; Zhu, R.; Cheng, J.; Yin, L. “Effective and Selective Anti-Cancer Protein Delivery via All-Function-in-One Nanocarriers Coupled with Visible Light-Responsive, Reversible Protein Engineering”, Adv. Funct. Mater., 2018, DOI: 10.1002/adfm.201706710.[PDF] [Link] [SI]

179. He, X.; Zhang, J.; Li, C.; Zhang, Y.; Lu, Y.; Zhang, Y.; Liu, L.; Ruan, C.; Chen, Q.; Chen, X.; Guo, X.; Sun, T.; Cheng, J.; Jiang, C. “Enhanced bioreduction-responsive diselenide-based dimeric prodrug nanoparticles for triple negative breast cancer therapy”, Theranostics, 2018, 8, 4884. [PDF] [Link
]

178. He, X.; Cai, K.; Zhang, Y.; Lu, Y.; Guo, Q.; Zhang, Y.; Liu, L.; Ruan, C.; Chen, Q.; Chen, X.; Li, C.; Sun, T.; Cheng, J.; Jiang, C. “Dimeric Prodrug Self-Delivery Nanoparticles with Enhanced Drug Loading and Bioreduction Responsiveness for Targeted Cancer Therapy”, ACS applied materials & interfaces, 2018, 10, 39455-39467. [PDF] [
Link

177. Ying, H.;  Yang, Y.; Cai, K.; Cheng, J. “Hindered Urea Bond: A Bilaterally Responsive Chemistry to Hydrogen Peroxide”, Eur. J. Org. Chem., 2019, 728-731.[PDF] [Link] [SI]

176. Liu, L.; Wang, R.; Wang, C.; Wang, J.;  Chen, L.; Cheng, J. “Light-triggered release of drug conjugates for an efficient combination of chemotherapy and photodynamic therapy”, Biomater. Sci., 2018,6, 997-1001. [PDF] [Link] [SI]

175. Liu, Y.; Song, Z.; Zheng, N.; Nagasaka, K.; Yin, L.; Cheng, J. “Systemic siRNA delivery to tumors by cell-penetrating α-helical polypeptide-based metastable nanoparticles”, Nanoscale, 2018, 10, 15339–15349.[PDF] [Link] [SI]

174. Wan, J.; Sun, L.; Wu, P.; Wang, F.; Guo, J.; Cheng, J.; Wang, C. “Light-triggered release of drug conjugates for an efficient combination of chemotherapy and photodynamic therapy”, Biomaterials Science, 2018, 6, 997-1001. [PDF] [Link]

173. Cai, K.; Ying, H.; Cheng, J. “Dynamic Ureas with Fast and pH-independent Hydrolytic Kinetics”, Chem. Eur. J., 2018, 24, 7345 –7348. [PDF] [Link] [SI]

172. Wang, R.; Cai, K.; Wang, H.; Yin, C.;  Cheng, J. “A caged metabolic precursor for DT-diaphorase responsive cell labeling”, Chem.Comm., 2018, 54, 4878–4881.[PDF] [Link]

171. Wan, J.; Sun, L.; Wu, P.; Wang, F.; Guo, J.; Cheng, J.; Wang, C. “Synthesis of indocyanine green functionalized comblike poly (aspartic acid) derivatives for enhanced cancer cell ablation by targeting the endoplasmic reticulum”, Polymer Chemistry, 2018, 9, 1206-1215. [PDF] [Link] [SI]

170. Yin, Q.; Tang, L.; Cai, K.; Yang, X.; Yin, L.; Zhang, Y.; Dobrucki, L.W.; Helferich, W.G.; Fan, T.M.; Cheng, J. “Albumin as a “Trojan Horse” for Polymeric Nanoconjugates Transendothelial Transport across Tumor Vasculatures for Improved Cancer Targeting”, Biomater. Sci., 2018, 6, 1189–1200. [PDF] [Link] [SI]

169. Wang, H.; Wang, R.; Cai, K.; He, H.; Liu, Y.; Yen, J.; Wang, Z.; Xu, M.; Sun, Y.; Zhou, X.; Yin, Q.; Tang, L.; Dobrucka, I.; Dobrucki, L.; Chaney, E.; Boppart, S.; Fan, T.; Lezmi, S.; Chen, X.; Yin, L.; Cheng, J. “Selective In Vivo Cell Labeling Mediated Cancer Targeting”, Nature Chemical Biology, 2017, 13, 415-424. [PDF] [Link] [SI]

168. Baumgartner, R., Fu, H.; Song, Z.; Lin, Y.; Cheng, J. “Cooperative polymerization of α-helices induced by macromolecular architecture”, Nature Chemistry, 2017, 9, 614–622. [PDF[Link] [SI]

167. Xiong, M.; Bao, Y.; Xu, X.; Wang, H.; Han, Z.; Wang, Z.; Liu, Y.; Huang, S.; Song, Z; Chen, J.; Peek, R.M. Jr., Yin, L.; Chen, L.; Cheng, J. “Selective Killing of Helicobacter pylori with pH-Responsive Helix-Coil Conformation Transitionable Antimicrobial Polypeptides”, PNAS, 2017, 114, 12675-12680. [PDF] [Link] [SI]

166. Song, Z.; Mansbach, R.A.; He, H.; Shik, K.C.; Baumgartner, R.; Zheng, N.; Ba, X.; Huang, Y.; Mani, D.; Nieh, M.P.; Ferguson, A.L.; Yin, L.; Cheng, J. “Modulation of Polypeptide Conformation through Donor-Acceptor Transformation of Side-Chain Hydrogen Bonding Ligands”, Nature Commun., 2017, 8, 92. [PDF] [Link] [SI]

165. Song, Z.; Han, Z.; Lv, S.; Chen, C.; Chen, L.; Lin, Y.; Cheng, J. “Synthetic polypeptides: from polymer design to supramolecular assembly and biomedical application”, Chem. Soc. Rev., 2017, 46, 6570-6599. [PDF] [Link]

164. Xiong, M.; Han, Z.; Song, Z.; Yu, J.; Ying, H.; Yin, L; Cheng, J. “Bacteria-Assisted Activation of Antimicrobial Polypeptides via Random Coil-to-Helix Transition”, Angew. Chem. Int. Ed., 2017, 56, 10826 –10829. [PDF] [Link] [SI]

163. Xia, H.; Fu, H.; Zhang, Y.; Shih, K.; Ren, Y.; Anuganti, M.; Nieh, M; Cheng, J.; Lin, Y. “Supramolecular Assembly of Comb-like Macromolecules Induced by Chemical Reactions that Modulate the Macromolecular Interactions in-situ”, J. Am. Chem. Soc., 2017, 139, 11106-11116. [PDF] [Link] [SI]

162. Chen, J.; Ding, J.; Wang, Y.; Cheng, J.; Ji, S.; Zhuang, X.; Chen, X. “Sequentially Responsive Shell-Stacked Nanoparticles for Deep Penetration into Solid Tumors”, Advanced Materials, 2017, 29. [PDF] [Link] [SI]

161. Lee, M.W.; Han, M.; Bossa, G.W.; Snell, C.; Song, Z.; Tang, T.; Yin, L.; Cheng, J.; May, S.; Luijten, E.; Wong, GC.L. “Interactions between Membranes and “Metaphilic” Polypeptide Architectures with Diverse Side-Chain Populations”, ACS Nano, 2017, 11, 2858-2871. [PDF] [Link] [SI]

160. Ying, H.; Yen, J.; Wang, R.; Lai, Y.; Hu, Y.; Cheng, J. “Degradable and biocompatible hydrogels bearing a hindered urea bond”, Biomater. Sci., 2017, 5, 2398–2402. [PDF] [Link

159. Zheng, N.; Song, Z.; Yang, J.; Liu, Y.; Li, F.; Cheng, J.; Yin, L. “Manipulating the membrane penetration mechanism of helical polypeptides via aromatic modification for efficient gene delivery”, Acta Biomaterialia., 2017, 58, 146–157. [PDF] [Link] [SI]

158. Ren, Y.; Baumgartner, R.; Fu, H.; Schoot, P.V.D.; Cheng, J.; Lin, Y. “Revisiting the Helical Cooperativity of Synthetic Polypeptides in Solution”, Biomacromolecules, 2017, 18, 2324-2332. [PDF] [Link] [SI]

157. Bao, Y.; Wu, X.; Chen, J.; Hu, X.; Zeng, F.; Cheng, J.; Jin, H. Lin, X.; Chen, L. “Brd4 modulates the innate immune response through Mnk2-eIF4E pathway-dependent translational control of IκBα”,  PNAS, 2017, 114, 3993-4001. [PDF] [Link] [SI]

156. Baumgartner, R.; Kuai, D.; Cheng, J. “Synthesis of controlled, high-molecular weight poly(L-glutamic acid) brush polymers”, Biomater. Sci., 2017, 5, 1836–1844. [PDF] [Link] [SI]

155. Ren, Y.; Fu, H.; Baumgartner, R.; Zhang, Y.; Cheng, J.; Lin, Y. “Folding Cooperativity of Synthetic Polypeptides with or without “Tertiary” Interactions”, ACS Macro Letter, 2017, 6, 733-737. [PDF] [Link] [SI]

154. Lv, S.; Tang, Z.; Song, W.; Zhang, D.; Li, m.; Liu, H.; Cheng, J.; Zhong, W.; Chen, X. “Inhibiting Solid Tumor Growth In Vivo by Non-Tumor-Penetrating Nanomedicine”, Small, 2017, 13,  1600954. DOI: 10.1002/smll.201600954. [PDF] [Link] [SI]

153. Zheng, N.; Song, Z.; Liu, Y.; Yin, L.; Cheng, J. “Gene delivery into isolated Arabidopsis thaliana protoplasts and intact leaves using cationic, α-helical polypeptide”, Front. Chem. Sci. Eng.,  2017, 11, 521–528. [PDF] [Link

152. Tian, J.; Rodgers, Z.; Min, Y.; Wan, X.; Qiu, H.; Mi, Y.; Tian, X.; Wagner, K.T.; Caster, J.M.; Qi, Y.; Roche, K.; Zhang, T.; Cheng, J.; Wang, A.Z. “Nanoparticle delivery of chemotherapy combination regimen improves the therapeutic efficacy in mouse models of lung cancer”, Nanomedicine: Nanotechnology, Biology, and Medicine, 2017, 13, 1301-1307. [PDF] [SI] [Link]

151. Cai, K.; Wang, A.Z.; Yin, L.; Cheng, J. “Bio-Nano Interface: The Impact of Biological Environment on Nanomaterials and Their Delivery Properties”, J. Controlled Release, 2017, 263, 211-222. [PDF] [Link

150. Lv, S.; Wu, Y.; Dang, J.; Tang, Z.; Song, Z.; Ma, S.; Wang, X.; Chen, X.; Cheng, J.; Yin, L. “Investigation on the controlled synthesis and post-modification of poly-[(N-2-hydroxyethyl)-aspartamide]-based polymers”, Polym. Chem., 2017, 8, 1872-1877.[PDF] [SI] [Link]


149. Song, Z.; Zhang, R.; Lu, H.; Gabrielson, N.P.; Yin, L.; Ponnusamy, E.; Cheng, J. “Synthesis and Biomedical Applications of Polyamino Acids”, Materials Matters, 2016, 8, 78-84. [PDF] [Link]

148. Wang, H.; Gauthier, M.; Kelly, J. R.; Miller, R.J.; Xu, M.; O’Brien, W.D.; Cheng, J. “Targeted Ultrasound Assisted Cancer-Selective Chemical Labeling and Subsequent Cancer Imaging via Click Chemistry”,
Angew. Chem. Int. Ed., 2016, 55, 5452-5456.  [PDF] [SI] [Link]

147. Wang, R.; Zhang, J.; Yin, Q.; Xu, Y.; Cheng, J.; Tong, R. “Controlled Ring-Opening Polymerization of O-Carboxyanhydrides Using β-Diiminate Zinc Catalyst”,
Angew. Chem. Int. Ed., 2016, 55, 13010-13014. [PDF] [SI] [Link]

146. Yin, Q.; Tang, L.; Cai, K.; Tong, R.; Sternberg, R.; Yang, X.; Dobrucki, L.W.; Borst, L.B.; Kamstock, D.; Song, Z.; Helferich, W.G.; Cheng, J.; Fan, T.M. “Pamidronate Functionalized Nanoconjugates for Targeted Therapy of Focal Skeletal Malignant Osteolysis”,
PNAS, 2016, 113, 4601-4609. [PDF] [SI] [Link]

145. Zhang, Y.; Ying, H.; Hart, K.R.; Wu, Y.; Hsu, A.J.; Coppola, A.M.; Kim, T.A.; Yang, K.; Sottos, N.R.; White, S.R.; Cheng, J. “Malleable and Recyclable Poly(urea-urethane) Thermoset Bearing Hindered Urea Bonds”, Advanced Materials, 2016, 28, 7646-7651. [PDF] [SI] [
Link]

144. Baumgartner, R.; Ryba, K.; Song, Z.; Wang, R.; Harris, K.; Katz, J.S.; Cheng, J.” A delayed curing ROMP based thermosetting resin”,
Polym. Chem., 2016, 7, 5093-5098.  [PDF] [SI] [Link]

143. Bai, Y.; Nguyen, L.T.; Song, Z.; Peng, S.; Lee, J.; Zheng, N.; Kapoor, I.; Hagler, L.D.; Cai, K.; Cheng, J.; Chan, H.Y.; Zimmerman, S.C. “Integrating Display and Delivery Functionality with a Cell Penetrating Peptide Mimic as a Scaffold for Intracellular Multivalent Multi-targeting”,
J. Am. Chem. Soc., 2016, 138, 9498-9507. [PDF] [SI] [Link]

142. He, H.; Zheng, N.; Song, Z.; Kim, K.H.; Yao, C.; Zhang, R.; Zhang, C.; Huang, Y.; Uckun, F.M.; Cheng, J.; Zhang, Y.; Yin, L. “Suppression of Hepatic Inflammation via Systemic siRNA Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide Hybrid Nanoparticles”,
ACS NANO, 2016, 10, 1859-1870. [PDF] [Link] [SI]

141. Kang, S.; Murphy, R.; Hwang, S.; Lee, S.; Harburg, D.; Krueger, N.; Shin, J.; Gamble, P.; Cheng, H.; Yu, S.; Liu, Z.; McCall, J.; Stephen, M.; Ying, H.; Kim, J.; Park, G.; Webb, R.; Lee, C.; Chung, S.; Wie, D.; Gujar, A.; Cheng, J.; Huang, Y.; Lee, S.; Braun, P.; Ray, W.; Rogers, J.A.“Bioresorbable Silicon Electronic Sensors for the Brain”, Nature,
2016, 530, 71-76. [PDF] [SI] [Link]

140. Wang, J.; Yuan, L.; Wang, Z.; Rahman, Md.A.; Huang, Y.; Zhu, T.; Wang, R.; Cheng, J.; Wang, C.; Chu, F.; Tang, C. “Photoinduced Metal-Free Atom Transfer Radical Polymerization of Biomass-Based Monomers”,
Macromolecules, 2016, 49, 7709-7717. [PDF] [SI] [Link]

139. Xing, H.; Xu, W.; Hwang, K.; Wu, P.; Yin, Q.; Li, Z.; Cheng, J.; Lu, Y. “The Effects of Spacer Length and Composition on Aptamer-Mediated Cell-Specific Targeting with Nanoscale PEGylated Liposomal Doxorubicin”,
Chem. Bio. Chem., 2016, 17, 1111-1117. [PDF] [SI] [
Link]

138. Song, Z.; Huang, Y.; Prasad, V.; Baumgartner, R.; Zhang, S.; Harris, K.; Katz, J.S.; Cheng, J. “Preparation of Surfactant-Resistant Polymersomes with Ultrathick Membranes through RAFT Dispersion Polymerization”, ACS Applied Materials & Interfaces,
2016, 8, 17033-17037. [PDF] [SI] [Link]

137. Azzi, J.; Yin, Q.; Uehara, M.; Ohori, S.; Tang, L.; Cai, K.; Ichimura, T.; McGrath, M.; Maarouf, M.; Kefaloyianni, E.; Loughhead, S.; Petr, J.; Sun, Q.; Kwon, M.; Tullius, M.; Andrian, U.; Cheng, J.; Abdi, R. “Targeted delivery of immunomodulators to lymph nodes”,
Cell Reports, 2016, 15, 1202-1213. [PDF] [SI[Link]

136. Wang, H.; Tang, L.; Liu, Y.; Dobrucki, I.T.; Dobrucki, L.W.; Yin, L.; Cheng, J.” In Vivo Targeting of Metabolically Labeled Cancers with Ultra-Small Silica Nanoconjugates”,
Theranostics, 2016, 6, 1467-1476. [PDF] [SI] [Link]

135. Ying, H.; Cheng, J. “One-step Construction of Aminosquaraine Backbone”,
Dyes and pigments, 2016, 131, 264-267. [PDF] [SI] [Link]

134. Li, Y.; Bai, Y.; Zheng, N.; Liu, Y.; Vincil, G.A.; Pedretti, B.J.; Cheng, J.; Zimmerman, S. “Crosslinked Dendronized Polyols as a General Approach to Brighter and More Stable Fluorophores”, Chem. Commun., 2016, 52, 3781-3784. [
PDF] [SI] [
Link]

133. Yen, J.; Ying, H.; Wang, H.; Yin, L.; Uckun, F.; Cheng, J. “CD44 Mediated Non-Viral Gene Delivery into Human Embryonic Stem Cells via Hyaluronic Acid Coated Nanoparticles”,
ACS Biomater. Sci. Eng., 2016, 2, 326-335.  [PDF] [Link]

132. Cheng, J.; Pun, S.H. “Polymeric biomaterials for cancer nanotechnology”, Biomater. Sci., 2015, 3, 891-893. [PDF] [Link]

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130. Torabi, S.F.; Wu, P.; McGhee, C.E.; Chen, L.; Hwang, K.; Zheng, N.; Cheng, J.; Lu, Y. “In vitro selection of a sodium-specific DNAzyme and its application in intracellular sensing”, PNAS, 2015, 112, 5903-5908.  [
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129. Cai, K.; He, X.; Song, Z.; Yin, Q.; Zhang, Y.; Uckun, F.M.; Jiang, C.; Cheng, J. “Dimeric Drug Polymeric Nanoparticles with Exceptionally High Drug Loading and Quantitative Loading Efficiency”, J. Am. Chem. Soc., 2015, 137, 3458-3461.  [PDF] [SI] [Link]

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127. Tang, L.; Yin, Q.; Xu, Y.; Zhou, Q.; Cai, K.; Yen, J.; Dobrucki, L.W.; Cheng, J. “Bioorthogonal Oxime Ligation Mediated in Vivo Cancer Targeting”, Chemical Science, 2015, 6, 2182-2186. [
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126. Tang, L.; Tong, R.; Coyle, V.J.; Yin, Q.; Pondenis, H.; Borst, L.B.; Cheng, J.; Fan, T.M. “Targeting Tumor Vasculature with Aptamer Functionalized Doxorubicin-Polylactide Nanoconjugates for Enhanced Cancer Therapy”, ACS Nano, 2015, 9, 5072-5081. [PDF] [SI] [Link]

125. Yin, Q.; Yin, L.; Wang, H.; Cheng, J. “Synthesis and biomedical applications of functional poly(alpha-hydroxy acids) via ring-opening polymerization of O-carboxyanhydrides”, Acc. Chem. Res., 2015, 48, 1777-1787. [PDF] [Link]

124. Wu, X.; He, C.; Wu, Y.; Chen, X.; Cheng, J. “Nanogel-Incorporated Physical and Chemical Hybrid Gels for Highly Effective Chemo-Protein Combination Therapy”, Adv. Funct. Mater., 2015, 25, 6744–6755. [
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123. Uckun, F.M.; Mitchell, L.G.; Qazi, S.; Myers, D.E.; Ma, H.; Zheng, N.; Song, Z.; Liu, Y.; Cheng, J. “Development of Polypeptide-Based Nanoparticles for Non-Viral Delivery of CD22 RNA Trans-splicing Molecule as a New Precision Medicine Candidate Against B-lineage ALL”, EBioMedicine, 2015, 2, 649-659. [PDF] [Link]

122. Uckun, F.M.; Qazi, S.; Cheng, J.; Myers, D.E. “Liposomal Nanoparticles of a Spleen Tyrosine Kinase P-site Inhibitor Amplify the Potency of Low Dose Total Body Irradiation Against Aggressive B-precursor Leukemia and Yield Superior Survival Outcomes in Mice EBioMedicine”, EBioMedicine, 2015, 2, 554-562. [
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121. Uckun, F.M.; Ma, H.; Cheng, J.; Myers, D.E.; Qazi, S. “CD22deltaE12 as a molecular target for RNAi therapy”, British Journal of Haematology, 2015, 169, 401-414.  [
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120. Wang, H.; Xu, M.; Xiong, M.; Cheng, J. “Reduction-Responsive Dithiomaleimide-Based Nanomedicine with High Drug Loading and FRET-Indicated Drug Release “, Chem. Commun., 2015, 51, 4807-4810. [
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119. Zhang, Y.; Yin, Q.; Yen, J.; Li, J.; Ying, H.; Wang, H.; Hua, Y.; Chaney, E.; Boppart, S.; Cheng, J. “Non-Invasive, Real-Time Reporting Drug Release In Vitro and In Vivo“, Chem.Commun., 2015, 51, 6948-6951. [
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118. Song, Z.; Kim, H.; Ba, X.; Baumgartner, R.; Lee, J.; Tang, H.; Leal, C.; Cheng, J. “Polypeptide Vesicles with Densely Packed Multilayer Membranes”, Soft Matter, 2015, 11, 4091-4098. [
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117. Baumgartner, R.; Song, Z.; Zhang, Y.; Cheng, J. “Functional Polyesters Derived from Alternating Copolymerization of Norbornene Anhydride and Epoxides”, Polym. Chem., 2015, 6, 3586-3590. [
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116. Andrade, B.; Song, Z.; Li, J.; Zimmerman, S.; Cheng, J.; Moore, J.S.; Harris, K.; Katz, J. “New Frontiers for Encapsulation in the Chemical Industry”, ACS Appl. Mater. Interfaces, 2015, 7, 6359−6368. [
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115. Wang, H.C.; Zhang, Y.; Possanza, C.; Zimmerman, S.; Cheng, J.; Moore, J.; Harris, K.; Katz, J. “Trigger Chemistries for Better Industrial Formulations”, ACS Appl. Mater. Interfaces, 2015, 7, 6369-6382. [
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114. Uckun, F.M.; Qazi, S.; Cheng, J. “Targeting leukemic stem cells with multifunctional bioactive polypeptide nanoparticles”, Future Oncology, 2015, 11, 1149-1152. (NIH-1DP2OD007246-01) [
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113. Lee, J.S.; Deng, X.; Han, P.; Cheng, J. “Dual Stimuli-Responsive Poly(beta-amino ester) Nanoparticles for On-Demand Burst Release”, Macromol. Biosci., 2015, 15, 1314-1322. (NIH-1DP2OD007246-01) [
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112. Zheng, N.; Song, Z.; Liu, Y.; Zhang, R.; Zhang, R.; Yao, C.; Uckun, F.M.; Yin, L.; Cheng, J. “Redox-responsive, reversibly-crosslinked thiolated cationic helical polypeptides for efficient siRNA encapsulation and delivery”, J. Controlled Release, 2015, 205, 231-239. [
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111. Cai, K.; Yen, J.; Yin, Q.; Liu, Y.; Song, Z.; Lezmi, S.; Zhang, Y.; Yang, X.; Helferich, W.G.; Cheng, J. “Redox-Responsive Self-Assembled Chain-Shattering Polymeric Therapeutics”, Biomater. Sci., 2015, 3, 1061-1065. [
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110. Ma, L.; Baumgartner, R.; Zhang, Y.; Song, Z.; Cai, K.; Cheng, J. “UV-Responsive Degradable Polymers Derived from 1-(4-Aminophenyl) ethane-1, 2-diol”, J. of Polym. Sci., Part A: Polym. Chem., 2015, 53, 1161-1168. [
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109. Gauthier, M.; Yin, Q.; Cheng, J.; O’Brien W.D. “Design of Albumin-Coated Microbubbles Loaded With Polylactide Nanoparticles”, J. Ultrasound Med., 2015, 34, 1363-1372. [
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108. Yin, L.; Chen, Y.; Zhang, Z.; Yin, Q.; Zheng, N.; Cheng, J. “Biodegradable Micelles Capable of Mannose-Mediated Targeted Drug Delivery to Cancer Cells”, Macromol. Rapid Commun., 2015, 36, 483-489.  [PDF] [SI] [Link]

107. Zhang, R.; Song, Z.; Yin, L.; Lu, H.; Gabrielson, N.P.; Cheng, J. “Ionic α-Helical Polypeptides towards Non-Viral Gene Delivery”, WIREs Nanomedicine & Nanobiotechnology, 2015, 7, 98-110. [PDF] [Link]

106. Mahsan, K.; Chaudhury, I.; Cheng, J.; Safari, M.; Sadeghi, R.; Habibi-Rezaei, M.; Kokini, J. “Immobilization of endo-inulinase on non-porous aminofunctionalized silica nanoparticles”, Journal of Molecular Catalysis B: Enzymatic, 2014, 104, 48-55. [
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105. Qu, Q.; Dong, L.; Louis, K.R.; Li, X.; Yang, H.; Sun, Q.; Crandall, S.R.; Tsang, S.; Zhou, J.; Cox, C.L.; Cheng, J.; Wang, F. “High-efficiency motor neuron differentiation from human pluripotent stem cells and the function of Islet-1”, Nature Communications, 2014, 5, 3449. [
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104. Ying, H.; Zhang, Y.; Cheng, J. “Dynamic urea bond for the design of reversible and self-healing polymers”, Nature Communications, 2014, 5, 3218. [
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103. Tang, L.; Yang, X.; Yin, Q.; Cai, K.; Wang, H.; Chaudhury, I.; Yao, C.; Zhou, Q.; Kwon, M.; Hartman, J.A.; Dobrucki, I.T.; Dobrucki, L.W.; Borst, L.B.; Lezmi, S.; Helferich, W.G.; Ferguson, A.L.; Fan, T.M.; Cheng, J. “Investigating the optimal size of anticancer nanomedicine”, PNAS, 2014, 111, 15344-15349. [
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102. Ying, H.; Cheng, J. “Hydrolysable Polyureas Bearing Hindered Urea Bonds”, J. Am. Chem. Soc., 2014, 136, 16974-16977. [PDF] [SI] [Link]

101. Uckun, F.M.; Qazi, S.; Ma, H.; Yin, L.; Cheng, J. “A rationally designed nanoparticle for RNA interference therapy in B-lineage lymphoid malignancies”, EBioMedicine, 2014, 1, 141-155. [
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100. Yin, L.; Huang, X.; Xu, H.; Zhang, Y.; Lam, J.; Cheng, J.; Rogers, J.A. “Materials, Designs, and Operational Characteristics for Fully Biodegradable Primary Batteries”, Advanced Materials, 2014, 26, 3879-3884. [PDF] [SI] [Link]

99. Yen, J.; Yin, L.; Cheng, J. “Enhanced Non-Viral Gene Delivery to Human Embryonic Stem Cells via Small Molecule-Mediated Transient Alteration of Cell Structure”, J. Mater. Chem. B., 2014, 2, 8098-8105. [
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98. Zhang, Y.; Wang, R.; Hua, Y.; Baumgartner, R.; Cheng, J. “Trigger-Responsive Poly(β-amino ester) Hydrogels”, ACS Macro Letters, 2014, 3, 693-697. [
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97. Tong, R.; Tang, L.; Ma, L.; Tu, C.; Baumgartner, R.; Cheng, J. “Smart Chemistry in Polymeric Nanomedicines”, Chem. Soc. Rev., 2014, 43, 6982-7012. [
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96. Myers, D.E.; Yiv, S.; Qazi, S.; Ma, H.; Cely, I.; Shahidzadeh, A.; Arellano, M.; Finestone, E.; Gaynon, P.; Termuhlen, A.; Cheng, J.; Uckun, F. “CD19-antigen Q1 specific nanoscale liposomal formulation of a SYK Q2 P-site inhibitor causes apoptotic destruction of human B-precursor leukemia cells”, Integr. Biol., 2014, 6, 766-780. [PDF] [Link]

95. Zheng, C.; Niu, L.; Pan, W.; Zhou, J.; Lv, H.; Cheng, J.; Liang, D. “Long-term kinetics of DNA interacting with polycations”, Polymer, 2014, 13, 2464- 2471. [
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94. Karimi, M.; Chaudhury, I.; Cheng, J.; Safari, M.; Sadeghi, R.; Habibi-Rezaei, M.; Kokini, J.;” Immobilization of endo-inulinase on non-porous aminofunctionalized silica nanoparticles”, Journal of Molecular Catalysis B: Enzymatic, 2014, 104, 48-55. [PDF] [Link]

93. Deng, X.; Zheng, N.; Song, Z.; Yin, L.; Cheng, J. “Trigger-responsive, fast-degradable poly(β-amin ester)s for enhanced DNA unpackaging and reduced toxicity”, Biomaterials, 2014, 35, 5006-5015. [
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92. Song, Z.; Zheng, N.; Ba, X.; Yin, L.; Zhang, R.; Ma, L.; Cheng, J. “Polypeptides with Quaternary Phosphonium Side Chains: Synthesis, Characterization, and Cell-Penetrating Properties”, Biomacromolecules, 2014, 15, 1491-1497.[
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91. Zhang, R.; Zheng, N.; Song, Z.; Yin, L.; Cheng, J.; “The effect of side-chain functionality and hydrophobicity on the gene delivery capabilities of cationic helical polypeptides”, Biomaterials, 2014, 35, 3443-3454. [
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90. Uppada, S.B.; Erickson, T.; Wojdyla, L.; Moravec, D.N.; Song, Z.; Cheng, J.; Puri, N. “Novel delivery system for T-oligo using a nanocomplex formed with an alpha helical peptide for melanoma therapy”, International Journal of Nanomedicine, 2014, 9. [
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89. Lu, H.; Wang, J.; Song, Z.; Yin, L.; Zhang, Y.; Tang, H.; Tu, C.; Lin, Y.; Cheng, J. “Recent Advances in Amino Acid N-Carboxyanhydrides and Synthetic Polypeptides: Chemistry, Self-Assembly and Biological Applications”, Chem. Commun., 2014, 50, 139-155. [PDF] [Link]

40. Chan, J.M.; Zhang, L. F.; Tong, R.; Ghosh, D.; Gao, W.; Liao, G.; Yuet, K.; Gray, D.; Rhee, J.W.; Cheng, J.; Golomb, G.; Libby, P; Langer, R.; Farokhzad, O. “Spatiotemporal Controlled Delivery of Nanoparticles to Injured Vasculature”, PNAS, 2010, 107, 2213-2218. [PDF] [Link]

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32. Tong, R.; Yala, L.; Fan, T.M.; Cheng, J. “The formulation of aptamer-coated paclitaxel-polylactide nanoconjugates and their targeting to cancer cells”, Biomaterials, 2010, 31, 3043-3053. [PDF] [Link]

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29. Tong, R.; Cheng, J. “Ring-Opening Polymerization Mediated-Controlled Formulation of Polylactide Nanoparticles”, J. Am. Chem. Soc., 2009, 131, 4744-4754. [PDF] [SI] [Link]

28. Yigit, M.V.; Mishra, A.; Tong, R.; Cheng, J.; Wong, G.C.L.; Lu, Y. “Inorganic mercury detection and controlled release of chelating agents from ion-responsive PEG-liposomes”, Chem. Biol., 2009, 16, 937-942. [PDF] [SI] [Link]

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85. Yin, L.; Song, Z.; Qu, Q.; Kim, K.H.; Zheng, N.; Yao, C.; Chaudhury, I.; Tang, H.; Gabrielson, N.P.; Uckun, F.M.; Cheng, J. “Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation”, Angew. Chem. Int. Ed., 2013, 52, 5757-5761. [PDF] [SI[Link]

84. Yin, L.; Tang, H.; Kim, K.; Zheng, N.; Song, Z.; Gabrielson, N.P.; Lu, H.; Cheng, J. “Light‐Responsive Helical Polypeptides Capable of Reducing Toxicity and Unpacking DNA: Toward Nonviral Gene Delivery”, Angew. Chem. Int. Ed. Engl., 2013, 52, 9182–9186.  [PDF] [SI] [Link]

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